In the 90's people were still using a phone like this one. Today, you need to go to an antique shop to find one. Well then, why do we still insist using the National Coverage Determination (NCD) 160/7 for Electrical Nerve Stimulators from August 7, 1995.
160/7 reads: "The implantation of the stimulator is used only as a late resort (if not a last resort) for patients with chronic intractable pain".
Today, we have so many modern neurostimulation options, including totally programmable pulse generator platforms that can accelerate medical research and time-to-market, literally down to a few months! Yet, instead of taking full advantage of the technological advancements, physicians resort to opioids, and at least some insurance companies hide behind the archaic 160/7.
Don't you think we should do something about it?
An interesting study on SCS with current-stim amplitudes below those evoking sensory perception ( sub-paresthesia) in alleviating pain. Please click here to access the source.
An interesting article on non-invasive neuromodulation therapy that provides symptomatic relief from hand tremor in essential tremor. For details please read the article.
Chronic pain patients want non-opioid options...
Please take a moment to read this article.
The pharmaceutical world is a very noisy place. TV channels air lots of “innocent! infomercials” depicting happy people, enjoying their lives in gorgeous locations. The people are all happy, therefore this must be a good product... right?
Well, when we see a commercial like that one, how many of us step back and think of the core value that the drug company stands for? Did they try to convince us to use their product or do they have a deeper and true desire to care and help people?
Not every company is the same of course, but please take a moment and read this CNN exclusive.
We must be the change we want to see, as the great Mahatma Gandhi once quoted. But, do we all have the time, the courage, the energy to change the status quo,? Even if it sounds impossible or crazy?
Before anything, we need to remember the core values we stand for: Do we or do we not believe we should improve lives without harming them? If we do, is it not the time to educate masses that opioids are not the right or the only choice for pain? There are other alternatives that are effective, safe and even reversible.
So, what are we waiting for?
Timothy R Deer president of the International Neuromodulation Society, makes the case for neurostimulation. Click here to read the article.
Researchers at the University of Washington are in a quest to create a device that would allow people who have been paralyzed by injury or stroke to move their limbs again. With a grant from the National Science Foundation, the goal is to make a device that would be implanted in the brain, interpret brain signals, and deliver the information to the appropriate region of the body.
The researchers are also exploring ways to power the implantable devices wirelessly, so that dependency on batteries can be eliminated.
Conventional spinal cord stimulation (SCS) delivers a fixed-input of energy into the dorsal column. A new SCS approach exists in controlling stimulation dose by measuring the recruitment of fibers in the dorsal column and by using the amplitude of the evoked compound action potentials (eCAPs) to maintain stimulation within an individualized therapeutic range. As a reminder, eCAP represents a synchronized response generated by a group of electrically activated nerve fibers to stimuli.
A key challenge in the measurement of evoked compound action potentials (eCAP) is the signal amplitude being very low. Spinal cord potential can be in the range of ten micro volts and a high precision (about one microvolt) measurement technique will be required to extract the eCAP. Further, if the initial stimulation potential is in volts, then stimulus artifacts would likely impact the evoked response unless the stimuli and measurement electrodes are spatially separated to minimize this artifact contamination.
Despite physical separation of stimuli from evoked signal measurement points, electrical circuit design techniques have critical impact on the measurement accuracy. Ideally a very high dynamic range circuit is desired to detect a very low signal from a high-amplitude stimulus but this is not practical.
Fortunately, there are several techniques in ultra-low noise amplifier design.
One may prefer to use an operational amplifier (Op Amp) or an instrumentation amplifier based design for simplicity, but a transistor-based discrete amplifier can have much lower noise, with a similar power consumption. Whether Op Amp or transistor based, noise of an amplifier can be reduced by paralleling amplifiers. This would lower noise by the square root of the number of parallel stages. A transistor-based design helps further, especially if JFET parts are used, since this would increase the input impedance.
It should be emphasized here that the resistor value selection is critical in low noise amplifier design, since a resistor contributes to circuit noise by about 4nV/rt Hz (nano volt per root hertz) for each 1 k ohms. In addition to its own noise contribution, resistor values also affect noise due to input noise current of amplifiers.
Each noise value Including the contribution of amplifier input noise voltage (multiplied by amplifier gain), amplifier output noise voltage, total circuit noise will add up as 'root of sums of squares of each contributor' and these can easily add up to hundreds of micro volts rms (root mean square) when calculated for the operating bandwidth of the circuit.
A low noise circuit designer should also be aware of the Gaussian distribution of random noise with the probability of +/- 3 sigma (6 sigma distribution). This implies 99.7% of total noise (in either plus and minus amplitude direction). This peak-to-peak noise will reach 6 times the rms value and can significantly shadow the low level evoked nerve signals being measured.
Please contact me if you are interested in additional details.