An interesting article on non-invasive neuromodulation therapy that provides symptomatic relief from hand tremor in essential tremor. For details please read the article.
Chronic pain patients want non-opioid options...
Please take a moment to read this article.
The pharmaceutical world is a very noisy place. TV channels air lots of “innocent! infomercials” depicting happy people, enjoying their lives in gorgeous locations. The people are all happy, therefore this must be a good product... right?
Well, when we see a commercial like that one, how many of us step back and think of the core value that the drug company stands for? Did they try to convince us to use their product or do they have a deeper and true desire to care and help people?
Not every company is the same of course, but please take a moment and read this CNN exclusive.
We must be the change we want to see, as the great Mahatma Gandhi once quoted. But, do we all have the time, the courage, the energy to change the status quo,? Even if it sounds impossible or crazy?
Before anything, we need to remember the core values we stand for: Do we or do we not believe we should improve lives without harming them? If we do, is it not the time to educate masses that opioids are not the right or the only choice for pain? There are other alternatives that are effective, safe and even reversible.
So, what are we waiting for?
Timothy R Deer president of the International Neuromodulation Society, makes the case for neurostimulation. Click here to read the article.
Researchers at the University of Washington are in a quest to create a device that would allow people who have been paralyzed by injury or stroke to move their limbs again. With a grant from the National Science Foundation, the goal is to make a device that would be implanted in the brain, interpret brain signals, and deliver the information to the appropriate region of the body.
The researchers are also exploring ways to power the implantable devices wirelessly, so that dependency on batteries can be eliminated.
Conventional spinal cord stimulation (SCS) delivers a fixed-input of energy into the dorsal column. A new SCS approach exists in controlling stimulation dose by measuring the recruitment of fibers in the dorsal column and by using the amplitude of the evoked compound action potentials (eCAPs) to maintain stimulation within an individualized therapeutic range. As a reminder, eCAP represents a synchronized response generated by a group of electrically activated nerve fibers to stimuli.
A key challenge in the measurement of evoked compound action potentials (eCAP) is the signal amplitude being very low. Spinal cord potential can be in the range of ten micro volts and a high precision (about one microvolt) measurement technique will be required to extract the eCAP. Further, if the initial stimulation potential is in volts, then stimulus artifacts would likely impact the evoked response unless the stimuli and measurement electrodes are spatially separated to minimize this artifact contamination.
Despite physical separation of stimuli from evoked signal measurement points, electrical circuit design techniques have critical impact on the measurement accuracy. Ideally a very high dynamic range circuit is desired to detect a very low signal from a high-amplitude stimulus but this is not practical.
Fortunately, there are several techniques in ultra-low noise amplifier design.
One may prefer to use an operational amplifier (Op Amp) or an instrumentation amplifier based design for simplicity, but a transistor-based discrete amplifier can have much lower noise, with a similar power consumption. Whether Op Amp or transistor based, noise of an amplifier can be reduced by paralleling amplifiers. This would lower noise by the square root of the number of parallel stages. A transistor-based design helps further, especially if JFET parts are used, since this would increase the input impedance.
It should be emphasized here that the resistor value selection is critical in low noise amplifier design, since a resistor contributes to circuit noise by about 4nV/rt Hz (nano volt per root hertz) for each 1 k ohms. In addition to its own noise contribution, resistor values also affect noise due to input noise current of amplifiers.
Each noise value Including the contribution of amplifier input noise voltage (multiplied by amplifier gain), amplifier output noise voltage, total circuit noise will add up as 'root of sums of squares of each contributor' and these can easily add up to hundreds of micro volts rms (root mean square) when calculated for the operating bandwidth of the circuit.
A low noise circuit designer should also be aware of the Gaussian distribution of random noise with the probability of +/- 3 sigma (6 sigma distribution). This implies 99.7% of total noise (in either plus and minus amplitude direction). This peak-to-peak noise will reach 6 times the rms value and can significantly shadow the low level evoked nerve signals being measured.
Please contact me if you are interested in additional details.
The results of a multicenter, double-blind, crossover, randomized controlled trial (RCT) that investigated the effects of rate of stimulation on analgesia in kilohertz frequency (1–10 kHz) spinal cord stimulation (SCS) suggests that patients experienced EQUIVALENT PAIN RELIEF as measured by (e-diary numeric rating scale) ED-NRS (p ≤ 0.002). For details, please see the source.
Patients were implanted with SCS systems and underwent an eight-week search to identify the best location (“sweet spot”) of stimulation at 10 kHz within the searched region (T8–T11). Patients who responded to 10 kHz per ED-NRS pain scores proceeded to double-blind rate randomization. Patients received 1, 4, 7, and 10 kHz SCS at the same sweet spot found for 10 kHz in randomized order (four weeks at each frequency). For each frequency, pulse width and amplitude were titrated to optimize therapy.
All frequencies provided equivalent pain relief, while 1 kHz requiring 60–70% less charge than higher frequencies (p ≤ 0.0002).
One important question is about the sensitivity of analgesia to frequencies outside the range of 1–10 kHz., both below and above.
Benefit of lower frequency would be even lesser charge for higher battery longevity and equivalent pain relief without paresthesia. Lower frequencies for SCS may be effective in the sub-perception modality (although, whether the mechanisms of action underlying burst SCS and kilohertz frequency SCS are the same is an open question). Other questions include whether the mechanisms of action for these two broad modalities of SCS (paresthesia and sub-perception) overlap in frequency range, and whether they can be engaged simultaneously to potentially yield an additive effect that further improves therapy.
The bottom line is: As fundamental understanding of mechanisms of action increases, continued optimization is likely and awaiting researchers.
A full-featured, fully programmable, pulse-generator platform such as Lone Star Neuro's 'indication agnostic platform' may be an ideal tool to empower institutions immediately to further medical research, since the platform can be set to deliver constant current or constant voltage pulses with programmable amplitude and pulse-width, at any frequency from 1 Hz to well above 40 (forty) kHz with simple C-code programming.
The heterogeneous and conductive nature of biological tissue render near-field inductive coupling ineffective in powering devices if implanted deeply. Similar to Lone Star Neuro's pulse-generator platform, SCMR (Strongly Coupled Magnetic Resonance) could overcome this limitation. If further device miniaturization is required, such as a device with dual electrodes and no batteries, mid-field power transfer can now be an option:
Power transfer in the mid-field region can (around a wavelength away from the source) transfer enough power to a millimeter scale implant deep inside a tissue. Further, mid-field region allows power flow lines to be manipulated with an interference pattern for focusing them in a specific spot, and well within the SAR (Specific Absorption Rate) safety limits.
Ho et al explain the theory behind mid-field power transfer, which is straightforward. Design and implementation of a mid-field power transmitter and a miniaturized receiver is also well within the capabilities of today's semiconductor components and manufacturing technologies, promising new millimeter-scale medical implants for a variety of therapy modalities which have not been feasible until recently.
Researchers at the University of California, San Francisco (UCSF), are developing an implantable artificial kidney that can closely replicate the functions of real kidneys. The Kidney Project is raising money to complete preclinical studies of the device modules and to build full-scale prototypes for the first round of human studies. Initial clinical trials on the individual modules are expected to begin early next year. Testing of a working prototype of the bioartificial kidney is slated for 2020.
Lone Star NeuroMODULATION
LSN is targeting unmet clinical needs by creating disruptive device platforms that offer promising solutions for lowering costs, realizing higher returns and effectively addressing more therapeutic indications if adopted for medical applications.